Conference abstract
Relationship between GGT and atherogenic index of plasma in cardiovascular risk assessment of hypertensive patients
Pan African Medical Journal - Conference Proceedings. 2023:17(130).04
Jun 2023.
doi: 10.11604/pamj-cp.2023.17.130.1548
Archived on: 04 Jun 2023
Contact the corresponding author
Keywords: Gamma Glutamyl Transpeptidase, atherogenic index plasma, cardiovascular risk
Poster
Relationship between GGT and atherogenic index of plasma in cardiovascular risk assessment of hypertensive patients
Valérie Ndobo Koe1,2,&, Nkeck JR2, Chemgne MI2, Ndjitoyap A2,3, Mfeukeu-Kuate L1,2, Ama Moor V2,4, Kingué S2,3
1Hôpital Central de Yaoundé, Yaoundé, Cameroun, 2Faculté de Médecine et Des Sciences Biomédicale de Yaoundé, Université de Yaoundé 1, Yaoundé, Cameroun, 3Hôpital Général de Yaoundé, Yaoundé, Cameroun, 4Centre Hospitalier Universitaire de Yaoundé, Yaoundé, Cameroun
&Corresponding author
Introduction: hypertension is the leading cause of cardiovascular death worldwide. In Europe and Asia, several studies have reported an association between gamma-glutamyl transpeptidases and the incidence of CV diseases due to the role of GGT in the advent of oxidative stress in atherosclerosis. However, it remains unknown whether GGT plays a direct role in the pathophysiology of atherosclerosis. The objective was to study the relationship between GGT and atherogenic plasma index in hypertensive patients' cardiovascular risk assessment.
Methods: we carried out a cross-sectional analytical study from November 2021 to May 2022 at the Yaoundé Central Hospital and at the Yaoundé University Teaching Hospital. Sampling was consecutive and non-exhaustive. We included hypertensive patients and excluded patients presenting any disease or medication that modified GGT or lipid profile. Demographic characteristics were recorded using a pre-defined questionnaire. Blood samples were collected for lipid profile and GGT testing. API was defined as log 10 (TG/HDLc). Statistical analyses with SPSS version 23.0. The significance level was set at 0.05
Results: we recruited 163 patients (101 females and 62 males) with a mean age of 57.71 years. There was a positively weak association between GGT, triglycerides, and API (p = 0.01; p = 0.02) respectively. There was no correlation between GGT, TC, and LDLc.
Conclusion: GGT influences API and could be used as biomarkers of atherosclerosis.
Relationship between GGT and atherogenic index of plasma in cardiovascular risk assessment of hypertensive patients
Valérie Ndobo Koe1,2,&, Nkeck JR2, Chemgne MI2, Ndjitoyap A2,3, Mfeukeu-Kuate L1,2, Ama Moor V2,4, Kingué S2,3
1Hôpital Central de Yaoundé, Yaoundé, Cameroun, 2Faculté de Médecine et Des Sciences Biomédicale de Yaoundé, Université de Yaoundé 1, Yaoundé, Cameroun, 3Hôpital Général de Yaoundé, Yaoundé, Cameroun, 4Centre Hospitalier Universitaire de Yaoundé, Yaoundé, Cameroun
&Corresponding author
Introduction: hypertension is the leading cause of cardiovascular death worldwide. In Europe and Asia, several studies have reported an association between gamma-glutamyl transpeptidases and the incidence of CV diseases due to the role of GGT in the advent of oxidative stress in atherosclerosis. However, it remains unknown whether GGT plays a direct role in the pathophysiology of atherosclerosis. The objective was to study the relationship between GGT and atherogenic plasma index in hypertensive patients' cardiovascular risk assessment.
Methods: we carried out a cross-sectional analytical study from November 2021 to May 2022 at the Yaoundé Central Hospital and at the Yaoundé University Teaching Hospital. Sampling was consecutive and non-exhaustive. We included hypertensive patients and excluded patients presenting any disease or medication that modified GGT or lipid profile. Demographic characteristics were recorded using a pre-defined questionnaire. Blood samples were collected for lipid profile and GGT testing. API was defined as log 10 (TG/HDLc). Statistical analyses with SPSS version 23.0. The significance level was set at 0.05
Results: we recruited 163 patients (101 females and 62 males) with a mean age of 57.71 years. There was a positively weak association between GGT, triglycerides, and API (p = 0.01; p = 0.02) respectively. There was no correlation between GGT, TC, and LDLc.
Conclusion: GGT influences API and could be used as biomarkers of atherosclerosis.
