Conference abstract
Impact of diabetes mellitus on treatment outcomes of patients with active pulmonary tuberculosis: a 5-years retrospective study at the Douala Laquintinie hospital
Pan African Medical Journal - Conference Proceedings. 2023:17(131).04
Jun 2023.
doi: 10.11604/pamj-cp.2023.17.131.1698
Archived on: 04 Jun 2023
Contact the corresponding author
Keywords: Pulmonary tuberculosis, diabetes mellitus, treatment outcome, prevalence
Poster
Impact of diabetes mellitus on treatment outcomes of patients with active pulmonary tuberculosis: a 5-years retrospective study at the Douala Laquintinie hospital
Laurent-Mireille Endale Mangamba1,2,&, Denis Georges Teuwafeu1,3, Adamou Dodo Balkissou4,5, Linda Tchiazah Ayaba1, Bertrand Hugo Mbatchou6,7, Vincent Verla Siysi1,3
1Faculty of Health Sciences, University of Buea, Cameroon, 2Douala Laquintinie Hospital, Douala, Cameroon, 3Buea Regional Hospital, Buea, Cameroon, 4Faculté de Médecine et des Sciences Biomédicales de Garoua, Université de N´Gaoundéré, Garoua, Cameroun, 5Hôpital Régional de Garoua, Garoua, Cameroun, 6Faculté de Médecine et des Sciences Pharmaceutiques, Université de Douala, Douala, Cameroun, 7Douala General Hospital, Douala, Cameroon
&Corresponding author
Introduction: the burden of diabetes mellitus-tuberculosis co-morbidity is a rising global health hazard with little data in our context. The objective of this study was to determine the prevalence of diabetes mellitus (DM) among pulmonary tuberculosis (PTB) patients, the treatment outcomes and the impact of DM on the treatment outcome of PTB at the Respiratory Disease Center of the Douala Laquintinie Hospital.
Methods: a 5-year hospital-based retrospective study was carried out from January 2016 – 2021. The chi-square test was used to test for association between dependent variables (treatment outcomes) and independent variables (sociodemographic characteristics and comorbidities). Bivariate and Multivariate logistic regression was used to identify factors and independent associations. Data were analyzed using SPSS version 25.
Results: out of 411 active pulmonary tuberculosis patients, 117 (29%) patients were diabetic (95% CI: 25.3% to 32.7%). The mean age of the study participants was 44.3 (SD11.6 years). Diabetic TB patients had higher odds (OR = 10.2) of having unsuccessful treatment outcomes than non-diabetic patients (35.2% vs. 15.4%) (p < 0.0001). Delayed sputum conversion time (4-5 months) (COR 4.48, p = 0.032) and a non-compliant diabetic status (COR 8.4, p = 0.005), were independently associated with a poor PTB treatment outcome. Factors associated with poor PTB treatment in diabetic patients include being underweight, chronic alcohol consumption, tobacco consumption, age over 40 years and being female (COR 1.175, p =0.675).
Conclusion: the prevalence of diabetes mellitus was high among pulmonary tuberculosis patients, with diabetic patients experiencing a poorer treatment outcome. A delayed sputum conversion and non-compliant diabetic status were strongly associated with a poor pulmonary tuberculosis treatment outcome.
Impact of diabetes mellitus on treatment outcomes of patients with active pulmonary tuberculosis: a 5-years retrospective study at the Douala Laquintinie hospital
Laurent-Mireille Endale Mangamba1,2,&, Denis Georges Teuwafeu1,3, Adamou Dodo Balkissou4,5, Linda Tchiazah Ayaba1, Bertrand Hugo Mbatchou6,7, Vincent Verla Siysi1,3
1Faculty of Health Sciences, University of Buea, Cameroon, 2Douala Laquintinie Hospital, Douala, Cameroon, 3Buea Regional Hospital, Buea, Cameroon, 4Faculté de Médecine et des Sciences Biomédicales de Garoua, Université de N´Gaoundéré, Garoua, Cameroun, 5Hôpital Régional de Garoua, Garoua, Cameroun, 6Faculté de Médecine et des Sciences Pharmaceutiques, Université de Douala, Douala, Cameroun, 7Douala General Hospital, Douala, Cameroon
&Corresponding author
Introduction: the burden of diabetes mellitus-tuberculosis co-morbidity is a rising global health hazard with little data in our context. The objective of this study was to determine the prevalence of diabetes mellitus (DM) among pulmonary tuberculosis (PTB) patients, the treatment outcomes and the impact of DM on the treatment outcome of PTB at the Respiratory Disease Center of the Douala Laquintinie Hospital.
Methods: a 5-year hospital-based retrospective study was carried out from January 2016 – 2021. The chi-square test was used to test for association between dependent variables (treatment outcomes) and independent variables (sociodemographic characteristics and comorbidities). Bivariate and Multivariate logistic regression was used to identify factors and independent associations. Data were analyzed using SPSS version 25.
Results: out of 411 active pulmonary tuberculosis patients, 117 (29%) patients were diabetic (95% CI: 25.3% to 32.7%). The mean age of the study participants was 44.3 (SD11.6 years). Diabetic TB patients had higher odds (OR = 10.2) of having unsuccessful treatment outcomes than non-diabetic patients (35.2% vs. 15.4%) (p < 0.0001). Delayed sputum conversion time (4-5 months) (COR 4.48, p = 0.032) and a non-compliant diabetic status (COR 8.4, p = 0.005), were independently associated with a poor PTB treatment outcome. Factors associated with poor PTB treatment in diabetic patients include being underweight, chronic alcohol consumption, tobacco consumption, age over 40 years and being female (COR 1.175, p =0.675).
Conclusion: the prevalence of diabetes mellitus was high among pulmonary tuberculosis patients, with diabetic patients experiencing a poorer treatment outcome. A delayed sputum conversion and non-compliant diabetic status were strongly associated with a poor pulmonary tuberculosis treatment outcome.
