Conference abstract
Incidence, clinical pattern and outcomes of sepsis in medical admissions at the Bamenda Regional Hospital
Pan African Medical Journal - Conference Proceedings. 2023:17(82).04
Jun 2023.
doi: 10.11604/pamj-cp.2023.17.82.1582
Archived on: 04 Jun 2023
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Keywords: Sepsis, incidence, mortality, length of hospital stay, medicine admissions, Cameroon, Bamenda
Poster
Incidence, clinical pattern and outcomes of sepsis in medical admissions at the Bamenda Regional Hospital
Alex Tatang Mambap1,2,&, Gaius Ejob Lanchia1, Anastase Dzudie3, Gloria Enow Ashuntantang1,4
1Department of Clinical Sciences, Faculty of Health Sciences, The University of Bamenda, Bamenda, Cameroon, 2Bamenda Regional Hospital, Bamenda, Cameroon, 3Faculty of Medicine and Pharmaceutical Sciences. The University of Douala, Douala, Cameroon, 4Department of Internal Medicine and Specialties. Faculty of Medicine and Biomedical Sciences, the University of Yaoundé I, Yaoundé, Cameroon, 5Yaoundé General Hospital, Yaoundé, Cameroon
&Corresponding author
Introduction: sepsis is a life-threatening infection-related complication in medical admissions, especially in low- and middle-income countries, and it is associated with significant mortality and morbidity. Data on the incidence and outcomes of sepsis are scarce in Sub-Saharan Africa (SSA), where endemic tropical infections and advanced HIV are prevalent. The objective of this study was to first determine the incidence of sepsis, as well as the impact of sepsis on the length of hospital stay and in-hospital mortality in adult medical admissions at the Bamenda Regional Hospital (a second-level referral hospital in Cameroon).
Methods: this hospital-based cohort study included patients who were admitted to our medical wards between March 1st and May 31st, 2021, and were diagnosed with infection during their stay. Those who chose to leave the study as well as those who left the hospital against medical advice were excluded. The quick sequential organ failure assessment (qSOFA) score was used to determine whether the patients had sepsis. Patients were followed until they were discharged, transferred to another hospital, or died. Sepsis was defined as a qSOFA score ≥ 2.
Results: our study included 152 participants in total. The median [IQR] age was 60 [42.0-72.0] years. The most common comorbidities were alcoholism (28.9%, n=44), HIV (18.4%, n=28), chronic kidney disease (16.4%, n=25), and heart failure (12.5%, n=19). Sepsis was found in 38.2% of patients. The most common sites of infection origin were the urinary tract (10.53%, n=16), nervous system (7.24%, n=11), and digestive system (6.58%, n=10). The overall mortality rate was 21.7%, with the sepsis group significantly higher than the non-sepsis group [48.3% VS 5.3%; p= 0.001]. The median [IQR] length of hospital stay in the sepsis group was significantly longer [8.0 VS 5.0, p =0.0018]. The factor associated with sepsis was diastolic hypotension (AOR=4.2; 95% CI=2.09-8.43; p=0.0036).
Conclusion: Bamenda Regional Hospital had a 38.2% sepsis incidence in medical admissions, with significant in-hospital mortality. Sepsis was associated with diastolic hypotension.
Incidence, clinical pattern and outcomes of sepsis in medical admissions at the Bamenda Regional Hospital
Alex Tatang Mambap1,2,&, Gaius Ejob Lanchia1, Anastase Dzudie3, Gloria Enow Ashuntantang1,4
1Department of Clinical Sciences, Faculty of Health Sciences, The University of Bamenda, Bamenda, Cameroon, 2Bamenda Regional Hospital, Bamenda, Cameroon, 3Faculty of Medicine and Pharmaceutical Sciences. The University of Douala, Douala, Cameroon, 4Department of Internal Medicine and Specialties. Faculty of Medicine and Biomedical Sciences, the University of Yaoundé I, Yaoundé, Cameroon, 5Yaoundé General Hospital, Yaoundé, Cameroon
&Corresponding author
Introduction: sepsis is a life-threatening infection-related complication in medical admissions, especially in low- and middle-income countries, and it is associated with significant mortality and morbidity. Data on the incidence and outcomes of sepsis are scarce in Sub-Saharan Africa (SSA), where endemic tropical infections and advanced HIV are prevalent. The objective of this study was to first determine the incidence of sepsis, as well as the impact of sepsis on the length of hospital stay and in-hospital mortality in adult medical admissions at the Bamenda Regional Hospital (a second-level referral hospital in Cameroon).
Methods: this hospital-based cohort study included patients who were admitted to our medical wards between March 1st and May 31st, 2021, and were diagnosed with infection during their stay. Those who chose to leave the study as well as those who left the hospital against medical advice were excluded. The quick sequential organ failure assessment (qSOFA) score was used to determine whether the patients had sepsis. Patients were followed until they were discharged, transferred to another hospital, or died. Sepsis was defined as a qSOFA score ≥ 2.
Results: our study included 152 participants in total. The median [IQR] age was 60 [42.0-72.0] years. The most common comorbidities were alcoholism (28.9%, n=44), HIV (18.4%, n=28), chronic kidney disease (16.4%, n=25), and heart failure (12.5%, n=19). Sepsis was found in 38.2% of patients. The most common sites of infection origin were the urinary tract (10.53%, n=16), nervous system (7.24%, n=11), and digestive system (6.58%, n=10). The overall mortality rate was 21.7%, with the sepsis group significantly higher than the non-sepsis group [48.3% VS 5.3%; p= 0.001]. The median [IQR] length of hospital stay in the sepsis group was significantly longer [8.0 VS 5.0, p =0.0018]. The factor associated with sepsis was diastolic hypotension (AOR=4.2; 95% CI=2.09-8.43; p=0.0036).
Conclusion: Bamenda Regional Hospital had a 38.2% sepsis incidence in medical admissions, with significant in-hospital mortality. Sepsis was associated with diastolic hypotension.
