Conference abstract
Leukocyte indices in non-diabetic hypertensive Cameroonians modestly predict cardiovascular risk: preliminary results of the HYRICCA project
Pan African Medical Journal - Conference Proceedings. 2023:17(96).04
Jun 2023.
doi: 10.11604/pamj-cp.2023.17.96.1528
Archived on: 04 Jun 2023
Contact the corresponding author
Keywords: Leukocyte indices, cardiovascular risk, arterial hypertension
Poster
Leukocyte indices in non-diabetic hypertensive Cameroonians modestly predict cardiovascular risk: preliminary results of the HYRICCA project
Jan René Nkeck1,2, Yondo Ndedi Claudine Jessica1,2,&, Mfeukeu Kuate Liliane1,3, Ndoumba Mintya Annick1,4, Chemgne Marie Ida1,2, Eko Ondoa Manuella1,2, Boukeu Yonta Charelle1,2, Zouague Zalbi Corine1,2, Ntyam Abena Andrée1,2, Falmata Amazia1,2, Jériel Pascal Nkeck1,2, Esther Astrid Mbono Samba1, Vicky Jocelyne Ama Moor1,2,5
1Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon, 2Groupe de Recherche HYRICCA (Hypertension et Risque Cardiovasculaire des Camerounais), Cameroon, 3Cardiology department, Yaoundé Central Hospital, Yaoundé, Cameroon, 4Hematology Laboratory, Yaoundé University Teaching Hospital, Yaoundé, Cameroon, 5Biochemistry Laboratory of the Yaoundé University Teaching Hospital, Yaoundé, Cameroon
&Corresponding author
Introduction: the full blood count is a routinely performed exam in the evaluation of hypertensive patients. However, the usefulness of leukocyte indices in cardiovascular risk assessment hasn’t yet been proven in our context. The objective was to study the contribution of leukocyte parameters in cardiovascular risk assessment of non-diabetic hypertensive adults
Methods: we carried out a cross-sectional study including non-diabetic hypertensive patients followed up at the cardiology unit of the Yaoundé Central Hospital from November to June 2022. The collected data included cardiovascular risk factors, biomarkers of risk (Hs CRP and atherogenic indices) and cardiovascular risk scores (Framingham 2008, European SCORE 2003, WHO CVD risk laboratory-based charts 2019, ASCVD 2013 and Reynolds score).
Results: we included 165 participants (102 females) with a mean age of 57.6 ± 10.4 years. The median duration of hypertension since diagnosis was 7 years and only 27% of participants on treatment had controlled blood pressure. There was a significantly weak and positive correlation between neutrophil to lymphocyte ratio and systolic blood pressure (rho = 0.24, p = 0.02). Participants with dyslipidemia had significantly raised levels of granulocyte count, eosinophil count and their corresponding leukocyte ratios (p Ë‚ 0.05). Highly sensitive CRP and the atherogenic index of plasma were significantly correlated respectively with the eosinophil to lymphocyte ratio (rho = 0.28, p = 0.01) and granulocyte to lymphocyte ratio (rho = 0.18, p = 0.03). There were also weak positive correlations between leukocyte parameters, Reynolds and ASCVD 2013 scores.
Conclusion: leukocyte indices could be useful in cardiovascular risk assessment of hypertensive patients.
Leukocyte indices in non-diabetic hypertensive Cameroonians modestly predict cardiovascular risk: preliminary results of the HYRICCA project
Jan René Nkeck1,2, Yondo Ndedi Claudine Jessica1,2,&, Mfeukeu Kuate Liliane1,3, Ndoumba Mintya Annick1,4, Chemgne Marie Ida1,2, Eko Ondoa Manuella1,2, Boukeu Yonta Charelle1,2, Zouague Zalbi Corine1,2, Ntyam Abena Andrée1,2, Falmata Amazia1,2, Jériel Pascal Nkeck1,2, Esther Astrid Mbono Samba1, Vicky Jocelyne Ama Moor1,2,5
1Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon, 2Groupe de Recherche HYRICCA (Hypertension et Risque Cardiovasculaire des Camerounais), Cameroon, 3Cardiology department, Yaoundé Central Hospital, Yaoundé, Cameroon, 4Hematology Laboratory, Yaoundé University Teaching Hospital, Yaoundé, Cameroon, 5Biochemistry Laboratory of the Yaoundé University Teaching Hospital, Yaoundé, Cameroon
&Corresponding author
Introduction: the full blood count is a routinely performed exam in the evaluation of hypertensive patients. However, the usefulness of leukocyte indices in cardiovascular risk assessment hasn’t yet been proven in our context. The objective was to study the contribution of leukocyte parameters in cardiovascular risk assessment of non-diabetic hypertensive adults
Methods: we carried out a cross-sectional study including non-diabetic hypertensive patients followed up at the cardiology unit of the Yaoundé Central Hospital from November to June 2022. The collected data included cardiovascular risk factors, biomarkers of risk (Hs CRP and atherogenic indices) and cardiovascular risk scores (Framingham 2008, European SCORE 2003, WHO CVD risk laboratory-based charts 2019, ASCVD 2013 and Reynolds score).
Results: we included 165 participants (102 females) with a mean age of 57.6 ± 10.4 years. The median duration of hypertension since diagnosis was 7 years and only 27% of participants on treatment had controlled blood pressure. There was a significantly weak and positive correlation between neutrophil to lymphocyte ratio and systolic blood pressure (rho = 0.24, p = 0.02). Participants with dyslipidemia had significantly raised levels of granulocyte count, eosinophil count and their corresponding leukocyte ratios (p Ë‚ 0.05). Highly sensitive CRP and the atherogenic index of plasma were significantly correlated respectively with the eosinophil to lymphocyte ratio (rho = 0.28, p = 0.01) and granulocyte to lymphocyte ratio (rho = 0.18, p = 0.03). There were also weak positive correlations between leukocyte parameters, Reynolds and ASCVD 2013 scores.
Conclusion: leukocyte indices could be useful in cardiovascular risk assessment of hypertensive patients.
