Conference abstract
The effect of antiretroviral therapy on renal and liver functions among hiv-infected patients attending Laquintinine Hospital Douala
Pan African Medical Journal - Conference Proceedings. 2023:18(139).03
Oct 2023.
doi: 10.11604/pamj-cp.2023.18.139.2249
Archived on: 03 Oct 2023
Contact the corresponding author
Keywords: HIV, antiretroviral therapy, renal, hepatotoxicity
Oral presentation
The effect of antiretroviral therapy on renal and liver functions among hiv-infected patients attending Laquintinine Hospital Douala
Takeh Roger Akonji1,&, Agbor Esther2, Takemegni Wandji Jonas Merlin1, Tiedam Atetsam Irene Laure1, Kagang Fodjo Ghislain Justice1
1Department of Medical Laboratory Sciences, University Institute of Gulf of Guinea, Douala, Cameroun/ University of Buea, Cameroon, 2University of Bamenda, Bamenda, Cameroon
&Auteur correspondant
Introduction: the use of highly active antiretroviral therapy (HAART) has improved the quality of life in HIV-infected patients on treatment in developed and developing countries. However, the main shortcoming of HAART in long-term use is its potential to cause liver and kidney problems that may be life threatening. This study was aimed to assess the effects of HAART on creatinine and ALT levels among HIV-infected patients attending Laquintinie Hospital Douala
Methods: a cross-sectional study conducted from April to July 2022 at the Laquintinie Hospital Douala on HIV-infected patients on HAART. Demographic data were collected using structured questionnaires. Information on HAART regimen, duration of HAART, with other clinical parameters were obtained from the medical records of subjects after informed consent. Serum creatinine and ALT activities were determined using the kinetic alkaline picrate method and spectrophotometry techniques respectively. Data were coded and analyzed using the SPSS version 20 software program. Descriptive statistics, tables, chi-square test, one-way analysis of variance, and logistic regression were done to determine associations. A P-value <0.05 was considered statistically significant.
Results: out of 93 participants, the mean age was 43.1±12.92 years. The majority of subjects (64.5%) were females. A higher proportion (40.8%) of participants were on TDF/3TC/EFV regimen followed by (35.5%) TDF/3TC/DTG regimen. The mean value of serum creatinine was (10.74±4.10 Vs 13.59±8.73 for ≤4 years and >4 years of therapy respectively) and ALT (28.35±17.55 vs 27.74±14.81) for patients after treatment was higher than values before treatment (10.14±3.77, 28.35±14.41 for creatinine and ALT respectively) but only creatinine was significant (P-value =0.036).ALT was higher for TDF/3TC/EFV (26.03±14.77) regimen users than for AZT/3TC/NVP (23.20±20.13) but was not significant with a minority 10(10.8%) developed grade 1 hepatotoxicity.
Conclusion: this study provides suggestive evidence that HIV and treatment with ART are associated with renal and liver dysfunction. The latency stage of HIV viruses is the possible way of incompletely killing HIV by present forms of therapeutics-including HAART. For this reason, the development of agents to specifically target latency states of HIV in new recipes of HAART therapeutics might be useful which includes a strategy of “flourish-and-kill.
The effect of antiretroviral therapy on renal and liver functions among hiv-infected patients attending Laquintinine Hospital Douala
Takeh Roger Akonji1,&, Agbor Esther2, Takemegni Wandji Jonas Merlin1, Tiedam Atetsam Irene Laure1, Kagang Fodjo Ghislain Justice1
1Department of Medical Laboratory Sciences, University Institute of Gulf of Guinea, Douala, Cameroun/ University of Buea, Cameroon, 2University of Bamenda, Bamenda, Cameroon
&Auteur correspondant
Introduction: the use of highly active antiretroviral therapy (HAART) has improved the quality of life in HIV-infected patients on treatment in developed and developing countries. However, the main shortcoming of HAART in long-term use is its potential to cause liver and kidney problems that may be life threatening. This study was aimed to assess the effects of HAART on creatinine and ALT levels among HIV-infected patients attending Laquintinie Hospital Douala
Methods: a cross-sectional study conducted from April to July 2022 at the Laquintinie Hospital Douala on HIV-infected patients on HAART. Demographic data were collected using structured questionnaires. Information on HAART regimen, duration of HAART, with other clinical parameters were obtained from the medical records of subjects after informed consent. Serum creatinine and ALT activities were determined using the kinetic alkaline picrate method and spectrophotometry techniques respectively. Data were coded and analyzed using the SPSS version 20 software program. Descriptive statistics, tables, chi-square test, one-way analysis of variance, and logistic regression were done to determine associations. A P-value <0.05 was considered statistically significant.
Results: out of 93 participants, the mean age was 43.1±12.92 years. The majority of subjects (64.5%) were females. A higher proportion (40.8%) of participants were on TDF/3TC/EFV regimen followed by (35.5%) TDF/3TC/DTG regimen. The mean value of serum creatinine was (10.74±4.10 Vs 13.59±8.73 for ≤4 years and >4 years of therapy respectively) and ALT (28.35±17.55 vs 27.74±14.81) for patients after treatment was higher than values before treatment (10.14±3.77, 28.35±14.41 for creatinine and ALT respectively) but only creatinine was significant (P-value =0.036).ALT was higher for TDF/3TC/EFV (26.03±14.77) regimen users than for AZT/3TC/NVP (23.20±20.13) but was not significant with a minority 10(10.8%) developed grade 1 hepatotoxicity.
Conclusion: this study provides suggestive evidence that HIV and treatment with ART are associated with renal and liver dysfunction. The latency stage of HIV viruses is the possible way of incompletely killing HIV by present forms of therapeutics-including HAART. For this reason, the development of agents to specifically target latency states of HIV in new recipes of HAART therapeutics might be useful which includes a strategy of “flourish-and-kill.
