Conference abstract
Evaluation of antibacterial and wound healing of crude extract leaves from Macaranga hurifolia (Euphorbiaceae)
Pan African Medical Journal - Conference Proceedings. 2023:18(181).03
Oct 2023.
doi: 10.11604/pamj-cp.2023.18.181.2004
Archived on: 03 Oct 2023
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Keywords: Macaranga hurifolia, wounds, antibacterial, ointments
Poster
Evaluation of antibacterial and wound healing of crude extract leaves from Macaranga hurifolia (Euphorbiaceae)
Fidèle Castro Weyepe Lah1,&, Patrick Herve Betote Diboue1
1Institut of Medical Research and Medicinal Plant Studies, Yaounde, Cameroon
&Corresponding author
Introduction: wound healing is a natural process that enables tissue repair after an injury. Currently, there is a growing interest in the use of alternative wound dressing agents such as plant extracts. One plant used traditionally in wound treatment is Macaranga hurifolia. The objective was to investigate the wound healing activities of 80% methanolic leave extract of Macaranga hurifolia. Also, its effects on four bacterial strains were investigated.
Methods: excision wounds were created, contaminated with microbes, and treated with ointments (10% and 20%w/w) prepared from Macaranga hurifolia. Incision and dead space wounds were also created in rats which were subsequently dosed orally with the extract. The wound healing activities of M. hurifolia ointment on excision wounds were assessed by rates of wound contraction and epithelialization and its antibacterial effects. The effects of M. hurifolia on incision and dead-space wounds were determined by the wound-breaking strengths and weights of the granuloma tissues formed, respectively.
Results: M. hurifolia ointments significantly (p < 0.05) accelerated wound healing with 20% ointment having the highest percentage of wound contraction and rate of epithelialization, at 4, 7, and 12 days post-treatment. Wound-breaking strengths and weights of granuloma tissues formed in the extract-treated groups were significantly (p < 0.05) higher than those of the control group. The minimum inhibitory concentration values obtained for the M. hurifolia extract against Haemophilus influenza, Klebsiella pneumonia, Pseudomonas aeruginosa, and Escherichia coli were 0.078 mg/ml, 2.5 mg/ml, 1.25 mg/ml and 2.5 mg/ml, respectively,
Conclusion: the results obtained showed that Macarnga hurifolia has good wound healing and antibacterial activities. These findings validate the use of this plant in traditional medicine for the treatment of wounds.
Evaluation of antibacterial and wound healing of crude extract leaves from Macaranga hurifolia (Euphorbiaceae)
Fidèle Castro Weyepe Lah1,&, Patrick Herve Betote Diboue1
1Institut of Medical Research and Medicinal Plant Studies, Yaounde, Cameroon
&Corresponding author
Introduction: wound healing is a natural process that enables tissue repair after an injury. Currently, there is a growing interest in the use of alternative wound dressing agents such as plant extracts. One plant used traditionally in wound treatment is Macaranga hurifolia. The objective was to investigate the wound healing activities of 80% methanolic leave extract of Macaranga hurifolia. Also, its effects on four bacterial strains were investigated.
Methods: excision wounds were created, contaminated with microbes, and treated with ointments (10% and 20%w/w) prepared from Macaranga hurifolia. Incision and dead space wounds were also created in rats which were subsequently dosed orally with the extract. The wound healing activities of M. hurifolia ointment on excision wounds were assessed by rates of wound contraction and epithelialization and its antibacterial effects. The effects of M. hurifolia on incision and dead-space wounds were determined by the wound-breaking strengths and weights of the granuloma tissues formed, respectively.
Results: M. hurifolia ointments significantly (p < 0.05) accelerated wound healing with 20% ointment having the highest percentage of wound contraction and rate of epithelialization, at 4, 7, and 12 days post-treatment. Wound-breaking strengths and weights of granuloma tissues formed in the extract-treated groups were significantly (p < 0.05) higher than those of the control group. The minimum inhibitory concentration values obtained for the M. hurifolia extract against Haemophilus influenza, Klebsiella pneumonia, Pseudomonas aeruginosa, and Escherichia coli were 0.078 mg/ml, 2.5 mg/ml, 1.25 mg/ml and 2.5 mg/ml, respectively,
Conclusion: the results obtained showed that Macarnga hurifolia has good wound healing and antibacterial activities. These findings validate the use of this plant in traditional medicine for the treatment of wounds.
