Conference abstract
Gamma-glutamyl transferases in association with cardiovascular risk scores in non-diabetic hypertensive Cameroonians
Pan African Medical Journal - Conference Proceedings. 2023:18(77).03
Oct 2023.
doi: 10.11604/pamj-cp.2023.18.77.2031
Archived on: 03 Oct 2023
Contact the corresponding author
Keywords: Gamma glutamyl transferase, hypertension, cardiovascular risk
Poster
Gamma-glutamyl transferases in association with cardiovascular risk scores in non-diabetic hypertensive Cameroonians
Nkeck JR1,&, Chemgne MI1
1Faculty of Médecine and Biomedical Sciences of the University of Yaounde I, Yaounde, Cameroun
&Corresponding author
Introduction: the usefulness of gamma-glutamyl transferase (GGT) as a biomarker of cardiovascular risk (CVR) remains unexplored in sub-Saharan Africans. This study aimed to evaluate their relevance in CVR assessment in non-diabetic hypertensive Cameroonians.
Methods: this was a prospective cross-sectional study on 163 non-diabetic hypertensive adults aged 57.7 ± 10 years (62% female), without evidence of acute or chronic liver disease, in which we assessed GGT levels and correlated it with validated CVR biomarkers, CVR scores (WHO risk score, Framingham 2008, ASCVD 2013, EuroSCORE 2003, and Reynolds score), and plasma atherogenic index (PAI).
Results: we found a positive but weak association between GGT and PAI on linear regression [0.004 (0.001; 0.007); p=0.021], which was dependent of triglyceride levels (r=0.17; p=0.03). We did not find a significant association between GGT levels and the results of the CVR scores studied.
Conclusion: although being related to atherogenic risk, as reported in the literature in non-sub-Saharan Africans, GGTs would be of little value for CVR assessment in our population.
Gamma-glutamyl transferases in association with cardiovascular risk scores in non-diabetic hypertensive Cameroonians
Nkeck JR1,&, Chemgne MI1
1Faculty of Médecine and Biomedical Sciences of the University of Yaounde I, Yaounde, Cameroun
&Corresponding author
Introduction: the usefulness of gamma-glutamyl transferase (GGT) as a biomarker of cardiovascular risk (CVR) remains unexplored in sub-Saharan Africans. This study aimed to evaluate their relevance in CVR assessment in non-diabetic hypertensive Cameroonians.
Methods: this was a prospective cross-sectional study on 163 non-diabetic hypertensive adults aged 57.7 ± 10 years (62% female), without evidence of acute or chronic liver disease, in which we assessed GGT levels and correlated it with validated CVR biomarkers, CVR scores (WHO risk score, Framingham 2008, ASCVD 2013, EuroSCORE 2003, and Reynolds score), and plasma atherogenic index (PAI).
Results: we found a positive but weak association between GGT and PAI on linear regression [0.004 (0.001; 0.007); p=0.021], which was dependent of triglyceride levels (r=0.17; p=0.03). We did not find a significant association between GGT levels and the results of the CVR scores studied.
Conclusion: although being related to atherogenic risk, as reported in the literature in non-sub-Saharan Africans, GGTs would be of little value for CVR assessment in our population.
